Up till now, genomics-based most cancers detection exams have relied on gene panels. A complete genome sequencing (WGS) take a look at has not been a viable choice for a number of causes, together with the expense and the massive quantity (and complexity) of the info generated. Nevertheless, given the falling price of subsequent technology sequencing (NGS), WGS might transfer into different areas the place it has beforehand not been possible. Younger Seok Ju, MD, PhD, co-founder and chief genomics officer of Genome Perception hopes that most cancers is a type of areas.
Ju has been working in NGS for the previous 15 years. His group’s focus is primarily bioinformatics, with an curiosity in most cancers genomics. A number of years in the past, whereas working in his lab on the Korea Superior Institute of Science and Expertise (KAIST), he determined to attempt to “use the know-how for the affected person.” Realizing that this endeavor was outdoors of academia, he fashioned Genome Perception three and a half years in the past in South Korea. The corporate, which has been working in R&D mode till now, moved its headquarters to San Diego a couple of 12 months in the past. Right now, the corporate is launching its medical service to sufferers as CancerVision. That is, they are saying, “their popping out celebration.”
They’re the primary firm, they famous, to carry WGS to routine care.
CancerVision combines the bioinformatics and computational sequencing developed within the Ju lab, of particular person affected person most cancers samples, to find out complete genome mutational profiles. To do that, a doctor sends the affected person’s samples (a tumor slide and a blood draw) to Genome Perception. The info are analyzed and curated for physicians in what the corporate calls an easy-to-use format that gives actionable insights.

Why may WGS be preferable to gene panels? The corporate’s CEO, Jehee Suh, tells GEN, that there are a number of benefits: WGS permits for a extra discovery-based method and doesn’t depend on a earlier speculation. Mutations past single nucleotide variants could be recognized comparable to advanced mutations and structural variants. WGS can decipher between somatic and hereditary mutations. Due to the massive variety of mutations recognized, and genomic panorama markers, the WGS take a look at can extra simply determine mutation signatures or patterns. Present panels are primarily based on widespread cancers, making uncommon cancers tougher to determine. Late-stage most cancers genes are uncared for within the present panels. Lastly, a doctor doesn’t want to decide on a panel, making it simpler for them to arrange the testing.
Genome Perception plans to fulfill a two-week turnaround time for CancerVision, and the purpose for the associated fee is on par with present exams (no larger than $2000/take a look at per affected person.) Following CancerVision, Genome Perception intends to broaden testing to genomic-based therapeutic areas past most cancers, together with uncommon illness.
The U.S. launch comes on the heels of information offered on the American Affiliation of Most cancers Analysis 2023 annual assembly wherein CancerVision demonstrated an evaluation of particular genetic mutations in breast cancers.
The corporate at present makes use of Illumina sequencing, however just lately introduced a collaboration with Ultima Genomics. Genome Perception doesn’t have a UG-100 at its headquarters in San Diego, however they anticipate the sequencing platform to reach within the second quarter of this 12 months. In the meanwhile, the 2 firms are collaborating on a most cancers pipeline whereas Ultima runs Genome Perception’s samples in-house.